It might be possible to make a skin to remove the buffs completely. I don't remember if I tried that by over-lapping the buffs/debuffs from the vital frames hmm.. But I think I haven't seen any skin mods here that would do that though.
Not sure if you mean that you want the most clutter-free skin available or something that would give you the most performance how your game runs.
There's a few skins somewhere here which are trying to minimize all the stuff you see on your screen while playing but they probably haven't been updated for quite a while (can't remember any names sorry).
If you just want a minimal UI to increase your framerate etc. there's no point as the skins have very little impact on how the game runs.
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